Lennox-Gastaut syndrome

Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide

OBJECTIVE This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable epileptic encephalopathy of early childhood. In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome. METHODS A systematic literature search (PubMed) was performed to review the existing literature pertaining to ...

A Dysbalanced Immune System in Cryptogenic Lennox-Gastaut Syndrome

Demonstration of antibody and cellular immune response to brain extract in West and Lennox-Gastaut syndromes.

We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of th...

A dysbalanced immune system in cryptogenic Lennox-Gastaut syndrome.

In children with cryptogenic Lennox-Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced-triggered as well as functionally impaired-immune system, has also been ...

A comparison of seizure outcome after callosotomy in patients with Lennox–Gastaut syndrome and a positive or negative history for West syndrome

PURPOSE This retrospective study was designed to clarify the role of West syndrome in post-callosotomy seizure outcome in patients with Lennox-Gastaut syndrome. METHODS From September 1989 to May 1999, 74 patients diagnosed with Lennox-Gastaut syndrome received anterior corpus callosotomy at Taipei Veterans General Hospital, Taiwan. All patients were followed for more than 4 years after surge...

Lacosamide-Induced Excessive Laughing in a Patient with Lennox–Gastaut Syndrome